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Dermamelan

Break Free from Melasma: Discover the Science Behind Dermamelan

Dermamelan by Mesoestetic is a professional depigmentation method specifically designed to treat the most resistant forms of hyperpigmentation, including melasma and post-inflammatory pigmentation.

Unlike treatments that fade pigmentation temporarily, Dermamelan addresses the underlying pathology, reducing pigment activity at its root. This makes it one of the most comprehensive solutions available in the aesthetic field.

Smiling woman sitting on a stool wearing a white shirt and jeans used in Dermamelan pigmentation treatment marketing
Dermal-Peel-1

Why Choose Dermamelan

Hyperpigmentation, melasma, and stubborn dark patches often leave clients feeling helpless after years of trial and error. At Jay’s Medispa, we understand how pigmentation can impact confidence, and we only offer treatments backed by science and clinical research.

Dermamelan is the world’s leading medical depigmentation treatment. Unlike creams or facials that only target surface-level pigmentation, Dermamelan works at the source, regulating the melanocytes (pigment-producing cells) to deliver long-lasting results. This is not just a cosmetic improvement—it’s a life-changing solution for those ready to reclaim clarity and confidence.

Benefits of the Treatment

Clinically proven to reduce melasma and resistant hyperpigmentation

Works at the cellular level to regulate pigment production

Effective across all skin types and tones

Noticeable improvement in skin brightness and clarity

Long-lasting results with proper maintenance

Improves overall skin quality, not just pigmentation

Common Issues This Treatment Addresses
Dermamelan is ideal for clients struggling with:
 
Melasma (hormonal pigmentation)
 
Chloasma (pregnancy-related pigmentation)
 
Post-Inflammatory Hyperpigmentation (PIH)
 
Solar Lentigines (sun spots)
 
Irregular Skin Tone and stubborn dark patches

Our Step-by-Step Approach

Step 1
Step 1: Consultation & Assessment

Every Dermamelan journey begins with a personalised consultation with one of our Registered Nurses. We’ll assess your skin, discuss your pigmentation concerns, and design a pre-treatment plan to prepare your skin for optimal results. You’ll begin using a prescribed retinol-based product to ready the skin and reduce downtime.

Step 2
Step 3
Step 4
Step 5
Step 6
Dermamelan treatment timeline showing consultation, mesopeel, and Dermamelan steps with a four-month structured regimen.

About the Manufacturer

Dermamelan is developed by Mesoestetic Pharma Group, a world-leading pharmaceutical company based in Barcelona, Spain, known for its medical-grade skincare and scientific excellence since 1985. Guided by a philosophy of science, integrity, and results, Mesoestetic formulates every product in-house under strict ISO 9001, 13485, and 22716 certifications, ensuring quality and safety at every step. Their innovations including PHOTON light-responsive systems, Shikimic Acid formulations, and patented Apigenin + Phloretin complexes are backed by clinical research and global collaborations in over 90 countries. We chose Mesoestetic because their evidence-based, ethical, and environmentally conscious approach aligns perfectly with our commitment to safety, integrity, and visible, confidence-restoring results.

Dermamelan vs. Cosmelan: What’s the Difference?

Both Dermamelan and Cosmelan are pigmentation treatments from Mesoestetic, but they serve slightly different purposes:
Dermamelan - Medical-grade depigmentation
  • Ideal for: Severe or resistant pigmentation, hormonal melasma, and long-standing discoloration

  • Depth of action: Works deeper within the skin to regulate overactive melanocytes

  • Results: Faster, more dramatic correction with visible improvements within a few weeks

  • Downtime: Mild to moderate peeling and redness for 5–10 days

  • Aftercare: Requires a dedicated home-care protocol and strict sun protection

  • Must Be Performed by: Medical professional under clinical supervision

Dermamelan offers a powerful, medical-grade solution for clients seeking to correct stubborn pigmentation at its source. It’s designed for those ready to take a decisive step toward lasting clarity and confidence, with visible transformation that continues to improve over time.

Cosmelan - Cosmetic-grade Depigmentation
  • Ideal for: Mild to moderate pigmentation, early melasma, or uneven skin tone

  • Depth of action: Gently renews the skin’s surface and helps regulate melanin activity

  • Results: Gradual improvement with a smoother, more even complexion over time

  • Downtime: Minimal redness or flaking for a few days

  • Aftercare: Simple home-care maintenance and daily SPF protection

  • Can Be Performed by: Qualified Beauty Therapist

Cosmelan provides a gentle yet effective path to brighter, more even skin. Perfect for first-time clients or those maintaining their results, it delivers a smoother, radiant complexion with minimal downtime and beautifully natural results.

Dermamelan Results

Pricing & Bookings

Dermamelan

Limited Time Offer

10% off Dermamelan Face treatment until 31 May 2026. T&Cs apply.

Single treatment

  • Dermamelan Face – Consultation, in-clinic treatment and homecare products ([duration]): was $2,400 / now $2,160

Terms and conditions

  • Offer applies to Dermamelan Face treatment
  • Bookings must be made online to receive the offer
  • Limit 1 offer per client
  • Consultation required prior to treatment to confirm suitability
  • Offer valid until 31 May 2026
Cosmelan - (Available by Special Request Only)

Cosmelan: Consultation, Pre-Treatment Peel & Products, Cosmelan Procedure, 4 Months of Homecare - $1,750

*Includes 1 x FREE LED Session 2 Months Post Treatment

FAQs

Let's explore some common questions about Dermamelan treatments.

Post-Treatment Care Guide

Following the aftercare protocol is essential for lasting results. Jay’s Medispa will provide your complete home-care kit and ongoing support.

Care Steps:

  • Apply prescribed Dermamelan home-care products exactly as directed.
  • Avoid direct sun exposure for 4 weeks; SPF 50+ is non-negotiable.
  • Avoid exfoliating products and active ingredients unless prescribed.
  • Stay hydrated and maintain a gentle skincare routine.
  • Contact Jay’s Medispa if you experience prolonged irritation.

This structured care ensures you achieve the best possible results with Dermamelan. Our team is with you at every step of the journey.

Known Side Effects

Most side effects are temporary and manageable:
  • Redness
  • Peeling and dryness
  • Mild swelling
  • Temporary sensitivity
  • Flushing or tightness
Dermamelan Treatment cream by Mesoestetic shown with product box for facial pigmentation control

Clinical Trials

At Jay’s Medispa, we believe in evidence-based treatments. Dermamelan is supported by published clinical research demonstrating its effectiveness for melasma and other pigmentation disorders.
“Efficacy and safety of a topical combination of depigmenting agents in the treatment of melasma”
Journal: Journal of Drugs in Dermatology, 2017
Protocol: 30 patients with moderate-to-severe melasma treated with Dermamelan protocol over 12 weeks.
Outcomes: Significant reduction in MASI (Melasma Area and Severity Index) scores; most patients reported high satisfaction.
Conclusion: Dermamelan is effective and well tolerated for melasma and resistant pigmentation.
 
“Evaluation of the efficacy of Dermamelan in refractory melasma: a prospective clinical study”
Journal: Clinical, Cosmetic and Investigational Dermatology, 2019
Protocol: 25 patients with resistant melasma underwent Dermamelan treatment with follow-up over 16 weeks.
Outcomes: Clear reduction in pigmentation intensity and MASI scores; minimal side effects reported.
Conclusion: Dermamelan offers a viable treatment for stubborn pigmentation unresponsive to other therapies.
 
“Long-term efficacy of Dermamelan depigmentation therapy in melasma”
Journal: Journal of Cosmetic Dermatology, 2020
Protocol: Patients treated with Dermamelan followed over 12 months.
Outcomes: Sustained reduction in pigmentation with proper maintenance; relapse was minimal when sun protection was observed.
Conclusion: Dermamelan provides long-lasting results, particularly when combined with sun care and maintenance.
 
Pigmentation doesn’t define you but it can affect how you feel. Dermamelan offers a proven path to clear, radiant skin when other treatments fall short. At Jay’s Medispa, we combine medical-grade treatments with a supportive, compassionate environment, helping you achieve results that last.
Book your Dermamelan consultation today and take the first step toward renewed clarity and confidence.

Industry Partners

Dermapen, Xeomin, Genosys, DP Dermaceuticals, O Cosmedics, and L’AIRE clinic logos displayed in a grid layout.
Professional aesthetic partner logos including Innoaesthetics, Inno-Derma, Belotero, Sunekos, Ultraformer III and Emsella
Partner logos for Classys, mesoestetic, Xytide Biotech, CryoPen, Dermamelan, BTL, and Cosmelan
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